国际医药卫生导报2010，Vol.16Issue(12)：1465-1467,3.DOI:10.3760/cma.j.issn.1007-1245.2010.12.022
甘精胰岛素联合格列美脲片治疗2型糖尿病的疗效观察
Efficacy of insulin glargine plus glimepiride for type 2 diabetes mellitus
谢彬 1熊晓清 1冉建民1
作者信息
- 1. 510220,广州市红十字会医院内分泌科
- 折叠
摘要
Abstract
Objective To investigate the efficacy and safety of insulin glargine plus glimepiride in the treatment of type 2 diabetic patients. Methods Sixty patients poorly responsive to oral sulfonylureas were randomly assigned to receive oral glimepiride plus injections of either insulin glargine (GL group, 30 patients) or neural protamine hagedorn (NPH group, 30 patients) for 12 weeks. Levels of fasting blood glucose and C-peptide, postprandial blood glucose and C-peptide, and HbAlc were detected 12 weeks after treatment. Results The fasting and postprandial blood glucose levels were significantly decreased. The incidence of hypoglycemia was lower in GL group than in NPH group (P<0.05) and C-peptide level was markedly higher. Conclusions Combination therapy with insulin glargine and glimepiride for type 2 diabetes is safe, effective, simple, and feasible. It can reduce the incidence of hypoglycemia and improve pancreatic function.关键词
2型糖尿病/甘精胰岛素/格列美脲片Key words
Type 2 diabetes mellitus/ Insulin glargine / Glimepiride tablets引用本文复制引用
谢彬,熊晓清,冉建民..甘精胰岛素联合格列美脲片治疗2型糖尿病的疗效观察[J].国际医药卫生导报,2010,16(12):1465-1467,3.
