首页|期刊导航|中华医学杂志（英文版）|Prediction of recurrence risk in early breast cancer using human epidermal growth factor 2 and cyclin A2
中华医学杂志（英文版）2010，Vol.123Issue(4)：431-437,7.DOI:10.3760/cma.j.issn.0366-6999.2010.04.009
Prediction of recurrence risk in early breast cancer using human epidermal growth factor 2 and cyclin A2
Prediction of recurrence risk in early breast cancer using human epidermal growth factor 2 and cyclin A2
摘要
Abstract
Background Human epidermal growth factor 2 (HER2) is one of the most important prediction factors, but only 25%-30% of breast cancer patients HER2 are positive. It is unknown whether there are other molecular markers that could be used to predict prognosis and recurrence in HER2 negative patients.This study investigated correlations of cyclin A2 and HER2 levels with clinical outcomes in 281 patients with invasive breast cancer in order to identify whether cyclin A2 can serve as a prognostic factor in HER2 negative patients.Methods Immunohistochemical staining was used to detect cyclin A2 and HER2 expression in 281 patients. Cyclin A2. and HER2 gene amplifications were analyzed using gene analysis and RT-PCR in 12 patients. Risk and survival estimates were analyzed using Log-rank, Kaplan-Meier, and Cox regression analysis; cyclin A2 and HER2 consistency with survival were analyzed using Kappa analysis.Results Patients with higher cyclin A2 and HER2 expressions had significantly shorter disease-free survival periods (P=0.047 and P=0.05, respectively). Kappa analysis performed that cyclin A2 and HER2 showed a low Kappa index (kappa=0.37), allowing us to conclude that cyclin A2 and HER2 detect different pathologies. Gene analysis and RT-PCR showed that cyclin A2 was upregulated in patients with early relapse; the average increase was 3.69-2.74 fold.Conclusions Cyclin A2 and HER2 are associated with proliferation and high recurrence, particularly when combined. Cyclin A2 is easily detected by nuclear staining and might be a useful biomarker for recurrence risk in HER2 negative patients.关键词
breast neoplasms/cyclin A2/human epidermal growth factor 2/prognosisKey words
breast neoplasms/cyclin A2/human epidermal growth factor 2/prognosis引用本文复制引用
LI Hui-ping,XIAO Yu,WANG You-fan,L(U) You-yong,SUN Yan,JI Jia-fu,HOU Kuan-yong,LEI Yu-tao,ZHAO Hong-mei,WANG Jing,ZHENG Jie,LIU Jian-ying,WANG Mo-pei..Prediction of recurrence risk in early breast cancer using human epidermal growth factor 2 and cyclin A2[J].中华医学杂志（英文版）,2010,123(4):431-437,7.基金项目
This project was supported by the grants from the National Natural Science Foundation of China (No. 30672424 and No. 30471684). （No. 30672424 and No. 30471684）
