中国卒中杂志2011，Vol.6Issue(1)：15-19,5.
成人烟雾病自然史初步研究
Natural History of Moyamoya Disease in Adult Patients
韩聪 1杨日淼 1段炼 1李志方 1史万超 1赵峰 1冯捷 1咸鹏 1杨伟中 1暴向阳1
作者信息
- 1. 100071,北京市,解放军307医院神经外科
- 折叠
摘要
Abstract
Objective The study aims to clarify the incidence and clinical features of disease progression in adult moyamoya disease.Methods From Dec.2002 to Oct.2009, 85 adult Chinese patients were diagnosed with moyamoya disease without any operation (a median time is 36 months).The symptoms at onset of all the case experiences are transient ischemic attack (TIA).Of these, 5 patients lost to follow.Disease progression occurred in 39 of 80 patients (48.75％ per patient) during the follow-up period.The progressive symptoms of 39 patients included infarct in 32 patients and intracranial bleeding in 7.The interval between their onset and disease progression is a mean period of 26 months (Q1 12 months, Q3 35.8 months).The patients without disease progression are 41 persons.To clarify the predictors of disease progression in adult moyamoya disease, univariate analysis were performed between the patients with and without disease progression.Subsequently, a multivariate logistic regression model was conducted to test the effect on disease progression.Results As the results of univariate analysis, there was a significant difference in onset age and TIA frequency change between the stable group(without disease progression)and the progression group(with disease progression)[32.0±8.0 years vs 35.7±6.8years (P＜0.05; 36.6％(15/41) vs 69.2％(27/39)].Multivariate logistic regression analysis showed that patients'TIA frequency change was an independent predictor of disease progression during follow-up periods (P＜0.05).The odds ratio conferred by a male patient was 3.899(95％CI 1.537-9.889) for disease progression.Conclusion The incidence of disease progression in adult moyamoya disease is much higher than recognized before, and that who has a higher TIA frequency may.be at higher risk for it.关键词
脑底异常血管网病/病史记录/卒中/危险因素引用本文复制引用
韩聪,杨日淼,段炼,李志方,史万超,赵峰,冯捷,咸鹏,杨伟中,暴向阳..成人烟雾病自然史初步研究[J].中国卒中杂志,2011,6(1):15-19,5.
