中山大学学报（医学科学版）2011，Vol.32Issue(1)：126-130,138,6.
他汀类药物预防脑卒中的meta分析
Meta-analysis of Statins for Stroke Prevention
摘要
Abstract
[Objective]To analyze the effects of satins for prevention of stroke. [Methods] Electronic databases from January 2002 to January 2010 about randomized controlled trial of statins were collected and meta-analysis of these randomized controlled trial was used. [Results] A total of 16 trials is included. Compared with control treatment, statin treatment reduced the risk of all stroke by 13％ (95％ CI 3％ ～ 22％ ,P = 0.01). After stratified, the morbidity of all stroke in patients with renal transplant and receiving haemodialysis because of nephropathy was increased by 21％ (95％ CI 0 ～ 46％, P = 0.05), and one of other stroke in patients was reduced by 19％ (95％ CI 13％ ～ 24％, P ＜ 0.001 ). Compared with control treatment, statin treatment reduced the morbidity of fatal stroke by 16％ (95％ CI 0％ ～ 30％, P = 0.05). There is not statistically significant about the morbidity of intracerebral haemorrhage between statin and control group (RR 1.18,95％ CI 0.92-1.50,P=0.19). [Conclusion] Statins can reduce the morbidity and mortality of stroke, but it can not prevent intracerebral haemorrhage and not increase the morbidity of intracerebral haemorrhage. However, we should be careful to use statins in patients with renal transplant and receiving haemodialysis because of nephropathy and history of intracerebral haemorrhage.关键词
他汀类药物/脑卒中/meta 分析分类
医药卫生引用本文复制引用
张炳俊,胡学强,陆正齐,李海燕..他汀类药物预防脑卒中的meta分析[J].中山大学学报（医学科学版）,2011,32(1):126-130,138,6.基金项目
国家自然科学基金(30971027) （30971027）
