浙江医学2011，Vol.33Issue(1)：15-17,3.
葡萄籽原花青素对血管性痴呆大鼠的治疗作用研究
The protective effect of grape seed proanthocyanidin on vascular dementia in rats
摘要
Abstract
Objective To investigate the effect of grape seed procyanidin(GSP) on vascular dementia (VD) in rats and its mechanism. Methods The vascular dementia was induced by occlusion of middle cerebral artery for 2h in rats. Fifty rats were randomly divided into five groups: sham operation group, VD group, positive control group (ginkgo biloba leaves extract), GSP group (50mgokg-1) and high-dose GSP group (100mgokg-1). The abilities of learning and memory in rats were measured by Morris water maze and step-down avoidance test. The contents of malondialdehyde (MDA), superoxide dismutase (SOD),cholinesterase (ChE), total antioxidant capacity (T-AOC) in brain tissue of ischemic hemisphere were measured. Results GSP significantly shortened the escape latency period and increased the frequency of crossing the former platform site in Morris water maze, extended the latency and decreased the frequency of errors in step-down avoidance test. GSP increased SOD and T-AOC contents,decreased ChE activity and MDA contents in brain tissue. Conclusion GSP has protective effect on vascular dementia in rats, which is associated with its effects on anti-oxidation, scavenging oxidation free radical and decreasing ChE activity.关键词
原花青素/大鼠/血管性痴呆/氧化应激引用本文复制引用
蒋国军,周恒,林焕冰,徐江平..葡萄籽原花青素对血管性痴呆大鼠的治疗作用研究[J].浙江医学,2011,33(1):15-17,3.基金项目
杭州市科技发展计划社会发展科研攻关项目(20070733B09) （20070733B09）
