中山大学学报（医学科学版）2011，Vol.32Issue(1)：31-38,8.
在肌腱损伤动物模型修复过程中BFGF和Ⅰ型胶原蛋白表达的特征
Characteristic Expression of BFGF and Collagen Type Ⅰ in Chicken Tendon Injury and Repair
摘要
Abstract
[Objective] In order to confirm the pathological changes in the lesion areas, and to investigate the function of BFGF and collagen type Ⅰ in the process of tendon injury and repair, the present study constructed the Leghorn chicken model of tendon injury and repair and carried out the exploration and evaluation utilizing the stereology,biomechanics,and immunohistochemistry. [ Methods] All the experimental data were statistically analyzed with SPSS10.0 software. [ Results]Our results showed that the degree of tendon adhesion and tensile strength gradually increased as the process of injury and repair continuing, and these degrees of the 6th week group were apparently higher than that of other experimental groups (P ＜ 0.001 ). Compared them between different time groups and the control group P ＜ 0.001. Large inflammatory and tendon cells were observed in the lesion areas, and the number of tendon cells in the 1-4 weeks groups were higher than that in the control group (P ＜ 0.05). The number of tendon cells reached the peak at the end of 2nd week (P ＜ 0.001 ), but the variance of macrophages quantities was not statistically significant among different time groups (P ＞ 0.05). The number of BFGF positive cells and expression of collagen type Ⅰ were higher in all experimental groups than that in the control group (P ＜ 0.05), and these results of the 2 weeks group were obviously higher than that of other experimental groups (P ＜ 0.001 ). Our results indicated that in the process of tendon injury and repair, the degree of tendon adhesion and tensile strength were positively correlated with the repair time. Histopathological changes and expression of BFGF and collagen type Ⅰ reached the peak at the end of 2nd week. [Conclusion]These characteristics suggested that BFGF and collagen type Ⅰ was correlated with the repair of injured tendon.关键词
肌腱/损伤修复/BFGF/Ⅰ型胶原蛋白分类
医药卫生引用本文复制引用
罗程,刘冰冰,欧阳丽斯,李可一,穆淑花,朱亚西,刘宗伟,詹玛琍,雷万龙..在肌腱损伤动物模型修复过程中BFGF和Ⅰ型胶原蛋白表达的特征[J].中山大学学报（医学科学版）,2011,32(1):31-38,8.基金项目
国家自然科学基金(30770679 （）
31070941 （）
20831006 （）
30570572) （）
