浙江医学2011，Vol.33Issue(1)：12-14,3.
柚皮苷抑制钛颗粒诱导糖尿病小鼠颅骨骨溶解的疗效观察
Naringin prevents calvarial osteolysis in titanium particle-induced diabetic mice
张招波 1周小小 1张鹏 2张超3
作者信息
- 1. 318000,浙江省恩泽医疗中心(集团)台州市中心医院骨科
- 2. 中国科学院深圳先进技术研究院生物医学与健康工程研究所转化医学研究与发展中心
- 3. 昆明医学院附属昆华医院骨科
- 折叠
摘要
Abstract
Objective To investigate the effect of naringin in preventing calvarial osteolysis of diabetic mice.Methods Sixty mice were randomly divided into nondiabetic and diabetic groups with 30 in each.Diabetes was induced by streptozotocin (STZ) injection.Diabetic and nondiabetic mice were further divided into 3 subgroups (10 in each subgroup), which were treated with vehicle, titanium particle and titanium particle plus naringin respectively for 10 days.BV/TV and BS/TV ratio was measured by microcomputed tomography ( μCT) scan and the alteration of bone indices near the midline suture was also measured.Serum levels of osteocalcin (OCN) and cross-linked N-telopeptide of type Ⅰ collagen (NTx) were detected by ELISA method.Results The bone formation (P ＞0.05), calvaria thickness (P ＞0.05), bone volume (BT/TV) (P ＞0.05), midline suture area (P ＞0.05) and OCN concentration (P ＞0.05) had no differences between diabetic mice treated with naringin and nondiabetic mice.Conclusion Naringin can prevent osteolysis in diabetic mice.关键词
骨形成/柚皮苷/骨溶解/骨碎补/糖尿病引用本文复制引用
张招波,周小小,张鹏,张超..柚皮苷抑制钛颗粒诱导糖尿病小鼠颅骨骨溶解的疗效观察[J].浙江医学,2011,33(1):12-14,3.
