浙江医学2011，Vol.33Issue(1)：35-36,91,3.
认知功能损害与缺血性脑白质病变的相关性研究
Correlation of white matter ischemic lesion with cognitive function impairment
吕祥兄 1方凯 1李晓彤 1石海涛1
作者信息
- 1. 311201,杭州,浙江萧山医院神经内科
- 折叠
摘要
Abstract
Objective To investigate the cognitive function impairment in patients with white matter ischemic lesions (WMIL). Methods The cognitive function of 30 patients with WMIL and 30 age and education-matched controls were measured using the Montreal Cognitive Assessment scale (MoCA). The severity of white matter lesions was scored and classified by the age-related white matter lesion scale (WMLs)and the cholinergic pathways hyperintensity scale (CHIPs). Results Compared with the controls, WMIL patients demonstrated decline in the cognitive function, especially in the language, memory, attention,visuoconstructional and executive functions, while the function of naming, abstraction and orientation showed no significant difference. In addition, the CHIPs scores were correlated with cognitive function,memory,attention,visuoconstructional and executive functions and WMLs scores were correlated with the angnitive function and visuoconstructiond and executivefunction. Conclusion WMIL patients demonstrated a selective impairment in cognitive function. The results suggest that the cognitive function may have different neuromechanisms and indicates cholinergic pathways may be the neuromechnism of the memory,attention,visuoconstructional and executive functions.关键词
脑白质病变/认知功能/胆碱能通路引用本文复制引用
吕祥兄,方凯,李晓彤,石海涛..认知功能损害与缺血性脑白质病变的相关性研究[J].浙江医学,2011,33(1):35-36,91,3.
