解放军医学杂志2011，Vol.36Issue(2)：122-124,3.
34例甲型H1N1流感危重症合并感染患者的病原菌分布情况分析
Distribution of pathogenic bacteria in 34 critical influenza A (H1N1) patients complicating bacteria infection
刘丽平 1石斌 1李斌 1郭鸿 1尹超 1张斌1
作者信息
- 1. 730000,兰州,兰州大学第一医院ICU
- 折叠
摘要
Abstract
Objective To investigate the distribution and the drug resistance of pathogenic bacteria in the patients with critical influenza A (H1N1) in the intensive care unit (ICU).Methods Pathogenic bacteria which infected the patients with influenza A (H1N1)in ICU of the first Hospital of Lanzhou University during Oct.2009 to Feb.2010, and their drug resistance were retrospectively analyzed.The correlation of these pathogenic bacteria and immune function of patients were also analyzed.Results Of 34 patients with influenza A (H1N1), 24 cases were cured and 10 cases died of influenza A (H1N1).Pathogenic bacteria were detected from 18 patients, the infection rate was 52.9％.Respiratory tract was the main infection site, accounting for 64.7％.Blood and venous catheters followed respectively,accounting for 13.2％ and 9.6％.A total of 136 strains of pathogenic bacteria were identified, they were successively as Acinetobacter baumannii (67.6％), Pseudomonas aeruginosa (9.6％), methicillin-resistant Staphylococcus aureus (6.7％), Escherichia coli (5.9％)and sleek Candida yeast (5.1 ％ ).For drug resistance, 63.0 ％ Acinetobacter baumanniis were resistant to all antibiotics except polymyxin B, and the rest were multi-resistant bacteria.Only 48.5％ Acinetobacter baumannii strains showed resistance to minocycline, and 59.3％Acinetobacter baumannii strains showed resistance to cefoperazone/sulbactam.A linear correlation existed between the number of Acinetobacter baumanniis strains and the CD4+/CD8+ ratio of T cell subsets (r＝0.973, P=0.027).Conclusions Strains of Acinetobacter baumannii, multi-drug-resistant strains or pan-drug-resistant strains, are the major pathogenic bacteria infecting the 34 patients with critical influenza A (H1N1).The number of Acinetobaceter bauanannii is significantly associated with the immune function of these patients.关键词
流感病毒A型,H1N1亚型/鲍曼不动杆菌/T淋巴细胞亚群Key words
influenza A virus/ H1N1 subtype/ Acinetobacter baumannii/ T-lymphocyte subsets分类
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刘丽平,石斌,李斌,郭鸿,尹超,张斌..34例甲型H1N1流感危重症合并感染患者的病原菌分布情况分析[J].解放军医学杂志,2011,36(2):122-124,3.
