军医进修学院学报2011，Vol.32Issue(2)：120-121,150,3.
阿尔茨海默病患者体内端粒甲基化分析
Methylation of telomeres in patients with Alzheimer's disease
摘要
Abstract
Objective To study the changing rules of telomere methylation in patients with Alzheimer's disease (AD). Methods Distribution of telomere methylation in peripheral blood of 39 patients with AD and 57 healthy controls was detected with restriction endonucleases Mspl and Hpall. Results The average length of telomeres detected with Mspl and Hpall in patients with AD and in healthy controls was not significantly different but negatively related with the age of patients with AD. The methylation extent of the longest telomere(＞9.4kb) and the shortest telomere (＜4.4kb) was significantly higher in patients with AD than in healthy controls (0.28 ± 0.16 vs 0.22 ± 0.12, P=0.021,0.24 ± 0.11 vs 0.46 ± 0.15, P＜0.001). Conclusion Accelerated methylation of telomeres in patients with AD is their aging-related features.关键词
阿尔茨海默病/端粒/甲基化Key words
Alzheimer Disease/ Telomere/ Methylation分类
医药卫生引用本文复制引用
管静芝,管维平,朱文华..阿尔茨海默病患者体内端粒甲基化分析[J].军医进修学院学报,2011,32(2):120-121,150,3.基金项目
解放军第309医院内科研启动基金(#09QD02) （#09QD02）
