中国药房2011，Vol.22Issue(3)：236-237,2.
野马追颗粒成型工艺考察及有效成分含量测定
Forming Process of Eupatorium lindleyanum Granules and Content Determination of Its Active Components
尹秀莲 1游庆红1
作者信息
- 1. 淮阴工学院生命科学与化学工程学院,淮安市,223003
- 折叠
摘要
Abstract
OBJECTIVE: To study the forming process of Eupatorium lindleyanum granules and to determine the content of its active component. METHODS: The forming process of E. lindleyanum granules was optimized by orthogonal experiment design using type of diluent, ratio of dry extract to soluble starch, concentration of ethanol, drying temperature as factors with eligible ratio,solution and retention rate as index. The contents of quercetin, kaempferide and isorhamnetin were determined by HPLC. RESULTS: The optimal forming process were as follows: soluble starch was used as diluent, ratio of dry extract to soluble starch was 1: 1.5, 95％ ethanol was used as wetting agent, drying temperature was 70℃. The linear range of quercetin, kaempferide and isorhamnetin was 0.065 6～0.328 0 μg(r=0.997 5) 、0.065 8～0.329 0 μg(r=0.995 9) 、0.025 4～0.127 0 μg(r=0.999 1) with average recovery of 99.6％、 101.2％ 、99.1％. The average contents of them were 0.9％, 0.6％, 0.2％. CONCLUSION: Prepared granules have good solubility with the high retention rate of active component. The method provides reference for industrial production of E.lindleyanum granules. HPLC method can be used for the content determination of quercetin, kaempferide and isorhamnetin of E.lindleyanum granules.关键词
野马追/颗粒剂/成型工艺/高效液相色谱法分类
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尹秀莲,游庆红..野马追颗粒成型工艺考察及有效成分含量测定[J].中国药房,2011,22(3):236-237,2.
