中国药房2011，Vol.22Issue(3)：201-203,3.
五指毛桃水提液对辐射致小鼠肺细胞DNA损伤的保护作用研究
Preventive Effect of Aqueous Extract from Ficus simplicissima on Radiation-induced DNA Injury of Lung Cells in Mice
摘要
Abstract
OBJECTIVE: To investigate the preventive effect of aqueous extract from Ficus simplicissima on 60Coγ ray-induced DNA injury of lung cells in mice. METHODS: The lung injury model was established by 60Coγ, ray whole lung irradiation. And the experiments included two parts, i.e. medication before radiation and after radiation. Each part had negative control group, radiation model group and high-dose, medium-dose and low-dose groups of aqueous extract from E simplicissima(20 g·kg-1, 10 g·kg-1,5 g·kg-1) via i.g. gtt. DNA damage was detected by single cell gel electrophoresis after 7 days of medication. RESULTS: The results showed that tail DNA％ and tail moment of lung cell DNA in radiation model group were higher than those of negative control group (P＜0.01). Tail DNA％ and tail moment of the experimental groups were significantly lower than those in radiation model group(P＜0.01). As the dose increased, the tail DNA％ and tail moment reduced. CONCLUSION: Aqueous extract from E simplicissima have certain preventive effect on radiation-induced DNA injury of lung cells in mice.关键词
五指毛桃/DNA损伤/单细胞凝胶电泳/防治作用/辐射分类
中医学引用本文复制引用
王晓平,黄翔,段丽菊,陆奇丰,岑业文..五指毛桃水提液对辐射致小鼠肺细胞DNA损伤的保护作用研究[J].中国药房,2011,22(3):201-203,3.基金项目
广西教育厅科研项目(200809MS124 （）
200911MSl95) （）
