中国药房2011，Vol.22Issue(3)：225-228,4.
正交试验优选春砂仁挥发油羟丙基-β-环糊精包合工艺
Optimization of the Preparation Technology of Amomum villous Oil-hydroxypropyl-β-Cyclodextrin Inclusion Complex by Orthogonal Experiment
摘要
Abstract
OBJECTIVE: To optimize the preparation technology of Amomum villous oil-hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion complex, and to identify the inclusion complex. METHODS: With the utilization ratio of volatile oil, ratio of oil content to the highest oil content and yield of inclusion complex as index, the stirring method, ultrasonic method and trituration method were optimized. The preparation technology of inclusion complex was optimized by orthogonal experiment taking the comprehensive evaluation score as index with ratio of volatile oil to HP-β-CD, concentration of HP-β-CD, inclusion time and inclusion temperature as factors. Microscopic identification method, DSC method, UV method and GC-MS method were used for the identification of inclusion complex. RESULTS: Ultrasonic method was the best preparation method, and the optimal preparation condition as following: the ratio of volatile oil to HP-β-CD was 1: 10 ( V: m), the concentration of HP-β-CD was 40％, the time and temperature for inclusion was 80 min and 55℃.No obvious change was found before and after inclusion. CONCLUSION: The optimized preparation technology of A. villous oil-hydroxypropyl-β-cyclodextrin is feasible and serves as reference for the production and research.关键词
春砂仁/挥发油/羟丙基-β-环糊精/包合物/制备工艺分类
医药卫生引用本文复制引用
张生潭,张帆,汪铁山,林敬明..正交试验优选春砂仁挥发油羟丙基-β-环糊精包合工艺[J].中国药房,2011,22(3):225-228,4.基金项目
广州市科技计划项目(2008Z1-E461) （2008Z1-E461）
