癌变·畸变·突变2011，Vol.23Issue(1)：9-12,4.DOI:10.3969/j.issn.1004-616x.2011.01.003
MnSOD基因单核苷酸多态性对食管癌局部放疗的影响
Influence of MnSOD gene polymorphism on the curative effect of radiotherapy in esophageal squamous cell carcinoma
摘要
Abstract
OBJECTIVE: To investigate the association of single nucleotide polymorphisms of (manganese superoxide dismutase, MnSOD) gene with radiosensitivity of esophageal squamous cell carcinoma. METHODS: The MnSOD Alal6Val was genotyped by polymerase-chain reaction-restriction fragment length polymorphism(PCR-RFLP)analysis in 93 esophageal squamous cell carcinoma patients. All patients received 3D-CRT or the conventional radiotherapy. RESULTS: The frequencies of T/T and C/T+C/C allelotype among three grades of curative effect were 59.1％, 40.9％; 77.8％, 22.2％; 62.5％, 37.5％ respectively. There was no statistical difference in allelotype distribution between three grades. When the length of esophagus cancer was 5 cm or less than there was no statistical difference in allelotype distribution between three grades of curative effect. But when the length was more than 5 cm a significant difference was observed in the MnSOD allelotype distribution among different length ( x 2＝2.658, P ＜ 0.05). The curative effect of radiotherapy in patients with C/T+C/C allelotype was better than patients with allelotype T/T when the length was more than 5 cm. There was no difference of MST and 1-year survival rates in patients with MnSOD-9 T/T genotype and MnSOD-9 T/C + C/C genotype(17 months, 68％, 35.82％ vs 22 months, 73％,34.62％ P＞0.05). CONCLUSION: The MnSOD Alal6Val appears to be associated with an improved radiosensitivity in patients when the length of esophagus lesion was more than 5 cm.关键词
食管癌/锰超氧化物歧化酶/单核苷酸多态性/放疗敏感性/局部疗效Key words
esophageal squamous cell carcinoma/ manganese superoxide dismutase/ single nucleotide polymorphism/ radiosensitivity/ curative effect分类
医药卫生引用本文复制引用
程云杰,王雅棣,刘青,张钧,万欣..MnSOD基因单核苷酸多态性对食管癌局部放疗的影响[J].癌变·畸变·突变,2011,23(1):9-12,4.基金项目
国家自然科学基金(30540005) （30540005）
教育部留学归国人员启动基金(30600047) （30600047）
河北省普通高等学校强势特色学科(群)资助项目 （群）
