北京大学学报（医学版）2011，Vol.43Issue(1)：102-105,4.DOI:10.3969/j.issn.1671-167X.2011.01.023
外放疗联合碘-125粒子植入治疗头颈癌的临床应用
Combined external radiotherapy and 125I-particle implantation for treatment of head and neck cancers
刘树铭 1孙艳 2郑磊 1张杰 1黄明伟 1朱京丽 3张祖燕 4张建国1
作者信息
- 1. 北京大学口腔医学院·口腔医院口腔颌面外科,北京,100081
- 2. 北京肿瘤医院放疗科,北京100142
- 3. 卫生部中日友好医院放疗科,北京100029
- 4. 北京大学口腔医学院·口腔医院放射科,北京100081
- 折叠
摘要
Abstract
Objective : To evaluate the relative incidence of local control and toxicity in patients with head and neck cancers who underwent external beam radiotherapy ( EBRT) plus 125 Ⅰ seeds implantation. Methods: Ten patients diagnosed as head and neck cancers at the department of oral and maxillofacial surgery of Peking University School of Stomatology during the period of February 2008 to July 2010 were collected. The histologic types included squamous cell carcinoma in 8 patients, poorly differentiated adenocarcinoma of salivary gland in 2 patients. All patients could not receive surgical treatment due to poor medical status or unresectable advanced-stage tumors and underwent EBRT plus 125Ⅰ seeds implantation. Eight patients with squamous cell carcinoma had conventional fractionated EBRT with a total dose of 50 Gy; two patients with poorly differentiated adenocarcinoma had conventional fractionated EBRT with a total dose of 70 Gy. They all then had 125Ⅰ seeds implantation with matched peripheral dose of 60 Gy ( TNM stage Ⅰ - Ⅱ ) or 80 Gy ( TNM stage Ⅲ - Ⅳ ) . The apparent activity per seed ranged from 25. 9 t0 29.6 MBq. Follow-up of the patients was done to analyze acute and late toxicity, local control, and survival. Results: After a median follow-up of 12 months ( range 2 -28 months) , soft tissue necrosis was seen in one patient, dysphagia and hemorrhage in another. No other serious side effects were observed. All the tumor mass of 10 cases disappeared within 6 months, regional metastases was observed in one patient, and distant metastases was observed in another. Seven of 10 patients survived till the date of investigation. Conclusion: External beam radiotherapy plus 125Ⅰ seeds implantation is a safe and effective therapy regimen for patients with unrectable head and neck cancers.关键词
近距离治疗/外放疗/碘-125粒子/头颈癌分类
医药卫生引用本文复制引用
刘树铭,孙艳,郑磊,张杰,黄明伟,朱京丽,张祖燕,张建国..外放疗联合碘-125粒子植入治疗头颈癌的临床应用[J].北京大学学报（医学版）,2011,43(1):102-105,4.
