北京大学学报（医学版）2011，Vol.43Issue(1)：112-116,5.DOI:10.3969/j.issn.1671-167X.2011.01.025
抗敏感牙膏缓解牙本质敏感的临床试验研究
A clinical study on the effectiveness of desensitizing toothpaste in patients with dentine hypersensitivity
梁妍 1荣文笙 2王伟健 2葛立宏2
作者信息
- 1. 北京朝阳瑞尔齿科诊所,北京,100004
- 2. 北京大学口腔医学院·口腔医院预防科,北京100081
- 折叠
摘要
Abstract
Objective : To evaluate the effectiveness of desensitizing toothpaste containing 5. 53％ potassium citrate on dentine hypersensitivity. Methods : This was a randomized, double-blinded, controlled, clinical trial. Those, who satisfied the inclusion criteria, were recruited into the study and randomized allocated into test group and control group according to gender and age group. At baseline, 67 subjects (36 in test group, 31 in control group) were recruited into the study. The dentine hypersensitivity was evaluated by a subject self-perceived short, sharp pain in visual analogue scale ( VAS) in response to a blast of cold air from a triple syringe administered to a tooth surface in 1 cm. Test toothpastes, containing 5. 53％ potassium citrate and 0. 76％ sodium monofluorophosphate, and control toothpastes, containing only 0.76％ sodium monofluorophosphate were delivered to the study subjects in the test and control group respectively. The subjects were asked to brush their teeth twice a day, and at least one minute each time. During the 8-week study period, a subjective evaluation of changes in the individuals overall sensitivity to everyday stimuli was also scored in VAS. Results : At the end of the trial data of 57 subjects (31 in test group, 26 in control group) was used for analysis. From baseline to 8-week evaluation, the mean VAS values to cold air and subjects' self-perceived VAS values of the subjects decreased both in the test and control groups. Furthermore , the reduction in mean VAS values to cold air from baseline to 4-week of the test subjects was statistically significant higher than that of the control ( 1. 12 vs. 0. 32, P ＜ 0. 05 ) . The reduction in mean subjects ' self-perceived VAS values from baseline to 8-week of the test subjects was statistically significant higher than that of the control ( 1. 59 vs, 0. 24 , P ＜ 0. 05 ) . Conclusion: Results of the clinical trial showed that toothpastes containing 5. 53％ potassium citrate were effective in reducing dentine hypersensitivity.关键词
牙本质过敏/牙膏/柠檬酸钾分类
医药卫生引用本文复制引用
梁妍,荣文笙,王伟健,葛立宏..抗敏感牙膏缓解牙本质敏感的临床试验研究[J].北京大学学报（医学版）,2011,43(1):112-116,5.
