中国药房2011，Vol.22Issue(7)：605-607,3.
夏天无总碱多囊脂质体的制备与体外特征评价
Preparation and in Vitro Evaluation of Corydalis decumbens Total Alkali Multivesicular Liposomes
摘要
Abstract
OBJECTIVE: To prepare Corydalis decumbens total alkali multivescular liposomes and evaluate it in vitro. METHODS: C. decumbens total alkali multivescular iiposomes were prepared by multiple emulsion method with encapsulation efficiency as index and with ratio of phospgatidycholine (PC) to drugs, ratio of PC to triolein (TO), ratio of OC to phosphatidylserine (PS) and ratio of PC to cholesterin (CH) as factors. The morphology, particle size, release in vitro of preparation were evaluated. RESULTS: The ratio of PC to drug, ratio of PC to TO, ratio of PC to PS and ratio of PC to CH were 10:2,3:1,4:3,1:2.5. The encapsulation efficiency of optimized formulation was (50 ± 3) ％. The multivescular liposomes assumed as spherical with average particle diameter of 22.0 μm. The drug release duration in normal saline was 2 days. CONCLUSION: The preparation technology is stable and feasible.关键词
夏天无总碱/多囊脂质体/制备/体外评价/缓释分类
医药卫生引用本文复制引用
刘芬,李良,钟海军,黄惠明,郭峰,徐春莲,徐卫国..夏天无总碱多囊脂质体的制备与体外特征评价[J].中国药房,2011,22(7):605-607,3.基金项目
江西省科技计划工业领域重点项目(2007BG13105) （2007BG13105）
