中国药房2011，Vol.22Issue(4)：338-339,2.
负荷量伊班膦酸钠治疗肺癌骨转移的临床观察
Clinical Observation of Loading Dose of Ibandronate in the Treatment of Bone Metastases of Non-small Cell Lung Cancer
关素梅 1张勇1
作者信息
- 1. 辽宁医学院附属第一医院,锦州市,121001
- 折叠
摘要
Abstract
OBJECTIVE: To evaluate the efficiency and safety of loading dose of ibandronate in the treatment of bone metastases of non-small cell lung cancer (NSCLC).METHODS: 33 patients with bone metastases of NSCLC admitted in our hospital during Oct.2008-Apr.2010 were analyzed retrospectively.Ibandronate was administered intravenously 4 mg for 4 days (total dose of 16 mg).The onset time, pain score, KPS score and daily consumption of morphine were recorded.The blood calcium, phosphate,alkaline phosphatase and renal function were monitored.RESULTS: After treatment, the rate of pain relief in 25 cases was 75.7％.The average onset time was (4.2 ± 0.9) days.The pain score was decreased after treatment.The life quality of patients was significantly improved.The consumption of morphine was reduced by about 40 mg to 100 mg in 15 cases after treatment.Ibandrouate was well tolerated with no evidence of renal toxicity.CONCLUSION: Loading dose of ibandronate has rapid onset and could relieve metastatic bone pain and improve life quality, reduce the consumption of morphine and avoid morphine-induced side effect.It is a good choice for opioid treatment of metastatic bone pain of malignant tumor关键词
非小细胞肺癌/骨转移/骨痛/伊班膦酸钠分类
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关素梅,张勇..负荷量伊班膦酸钠治疗肺癌骨转移的临床观察[J].中国药房,2011,22(4):338-339,2.
