中国药房2011，Vol.22Issue(4)：352-354,3.
氢氯噻嗪对高血压患者肾素-血管紧张素-醛固酮系统及生化指标的影响
Effects of Hydrochlorothiazide on Variety of Renin-angiotensin-aldosterone System and Biochemical Parameters in Hypertensive Patients
摘要
Abstract
OBJECTIVE: To observe the effects of different concentrations hydrochlorothiazide on variety of renin-angiotensin-aldosterone system and biochemical parameters in hypertensive patients. METHODS: 120 cases with mild to moderate hypertension received medical treatment in our hospital during 2009.1 -2010.7 They were randomly divided into 3 groups: control group (group A), HCTZ 12.5 mg group(group B) and HCTZ 25.0 mg group(group C).A group: 40 patients received 5 mg amlodipine,oral once every day; group B: 5 mg amlodipine+12.5 mg HCTZ; group C: 5 mg amlodipine +25.0 mg HCTZ. After 6 weeks, the RAAS activity and biochemical parameters of 3 groups were compared. RESULTS: The Ang Ⅱ and ALD in serum of group B after treatment was higher than that of group A(P＜0.05). Serum potassium, serum sodium and blood glucose did not change significantly. The Ang Ⅱ and ALD in serum of group C was higher than that of group B(P＜0.05). Serum potassium and serum sodium was lower. Blood glucose was higher. CONCLUSION: 12.5 mg HCTZ can activate the RAAS activity and 25.0 mg HCTZ has greater effect to biochemical parameters.关键词
肾素-血管紧张素-醛固酮系统/血糖/血钾分类
医药卫生引用本文复制引用
代大顺,曾垂义..氢氯噻嗪对高血压患者肾素-血管紧张素-醛固酮系统及生化指标的影响[J].中国药房,2011,22(4):352-354,3.
