中国药房2011，Vol.22Issue(7)：597-599,3.
因宁片对甲亢性肝损害大鼠肝脏Fas、FasL、TNF-α表达的影响
Effects of Yinning Tablets on the Expressions of Fas,FasL and TNF-α in Liver Tissue of Rats with Liver Injury Induced by Hyperthyroidism
周静 1王成蹊 1侯连兵1
作者信息
- 1. 南方医科大学南方医院药学部,广州市,510515
- 折叠
摘要
Abstract
OBJECTIVE: To study the effect of Yinning tablets on the expressions of Fas, FasL and TNF-α in liver tissue of rats with liver injury induced by hyperthyroidism.METHODS: Rats were intragastrically perfused with Levothyroxine sodium tables(800 μg·kg-1)to establish the rat model of hyperthyroidism-induced liver injury.Rats were treated with Yinning tablets at dose of 0.3, 0.6, 1.2 g· kg-1 and Jiakangling 0.6 g·kg-1 for 30 days, respectively.After treatment, liver samples were immediately collected.The pathological changes of liver tissue were observed under light microscope.The expressions of Fas, FasL and TNT-α were monitored by immunohistochemical method.RESULTS: The protein expression of Fas, FasL and TNF-α was significantly increased in liver of rats with hyperthyroidism-induced liver injury.Yinning tablets were able to down-regulate Fas, FasL and TNF-α expressions in liver of rats, and improve the pathological change of liver.CONCLUSION: Fas, FasL and TNF-α play important role in pathogenesis of liver injury induced by hyperthyroidism in rats.The protective role of Yinning tablets on liver injury induced by hyperthyroidism in rats is concerned with inhibiting the expression of Fas, FasL and TNF-α and apoptosis.关键词
因宁片/甲状腺功能亢进症/肝损害/脂肪酸合成酶/脂肪酸合成酶配体/肿瘤坏死因子-α分类
医药卫生引用本文复制引用
周静,王成蹊,侯连兵..因宁片对甲亢性肝损害大鼠肝脏Fas、FasL、TNF-α表达的影响[J].中国药房,2011,22(7):597-599,3.
