中国药房2011，Vol.22Issue(5)：428-430,3.
双氯芬酸钠-β-环糊精包合物口腔速崩片的处方及制备工艺研究
Study on the Formula and Preparation Technology of Diclofenac Sodium-β-CD Inclusion Complex Orally Disintegrating Tablets
摘要
Abstract
OBJECTIVE: To prepare the orally disintegrating tablets of diclofenac sodium-β-CD inclusion complex and to establish the formula and preparation technology of it. METHODS: With disintegration time as index, 5 kinds of disintegrating agents,2 kinds of lubricants, 3 kinds of hardness scopes and 2 kinds of preparation technologies were screened to obtain and validate optimal formula and prescription technology. RESULTS: Wet granule compression tablet method was used to prepare orally disintegrating tablet with crospovidone as disintegrating agent, aerosil and talc as the lubricant, and the hardness was 20～30 N. The prepared tablets could disintegrate completely within 60 s. CONCLUSION: The orally disintegrating tablets of diclofenac sodium is prepared after being included with β-CD. The method is simple and up to the standard of quality for the industrial production of diclofenac sodium-β-CD inclusion complex orally disintegrating tablets.关键词
双氯芬酸钠/口腔速崩片/β-环糊精/包合物/处方/制备工艺分类
医药卫生引用本文复制引用
王晓明,阴元魁..双氯芬酸钠-β-环糊精包合物口腔速崩片的处方及制备工艺研究[J].中国药房,2011,22(5):428-430,3.
