高校化学工程学报2011，Vol.25Issue(1)：123-128,6.
HPMC/PNIPAAm温度敏感性水凝胶的制备及其对5-氟尿嘧啶的控制释放
Preparation of Thermo-Sensitive HPMC/PNIPAAm Hydrogel and its Controlled Drug Delivery of 5- Fluorouracil
摘要
Abstract
Using linear HPMC (hydroxypropylmethyl cellulose) and NIPAAm (N-isopropylacrylamide) as raw materials, the temperature-sensitive hydrogels HPMC/PNIPAAm were prepared via the semi-IPN technique.The prepared hydrogels were characterized by Fourier transform infrared (FT-IR) spectroscopy, and their interior morphologies were observed by fluorescent microscope. The thermo-sensitivity, equilibrium swelling ratio and swelling dynamics of the prepared hydrogels were investigated, and the 5-fluorouracil was selected to be used as the model drug for examining the controlled drug release property of the prepared hydrogels. The results show that the swelling ratios of the hydrogels decrease with increasing temperature; and it was found that, the drug release rate of the hydrogel can be controlled by adjusting its HPMC content and the temperature of releasing. In pH 7.4 buffer solution (37℃), the prepared hydrogel PNI-H01, which was prepared with the weight ratio of HPMC to NIPAAm being 1/100, has the maximal swelling ratio and the fastest drug release rate.The obtained results suggest that the HPMC/PNIPAAm hydrogel would be a potential thermo-sensifive gel for oral drug delivery.关键词
羟丙基甲基纤维素/N-异丙基丙烯酰胺/温敏凝胶/5-氟尿嘧啶Key words
hydroxypropylmethyl cellulose/ N-isopropylacrylamide/ thermo-sensitive hydrogel/5- fluorouracil分类
自科综合引用本文复制引用
肖玉良,段桂运,李玉琴,夏成才,郑连英..HPMC/PNIPAAm温度敏感性水凝胶的制备及其对5-氟尿嘧啶的控制释放[J].高校化学工程学报,2011,25(1):123-128,6.基金项目
山东省自然科学重点基金(Y2007C135)资助项目 （Y2007C135）
山东省高等学校科技计划项目(J09LF76)资助项目. （J09LF76）
