量子电子学报2011，Vol.28Issue(1)：91-95,5.DOI:10.3969/j.issn.1007-5461.2011.01.015
激光诱导间质热疗中生物组织吸收系数变化特性研究
Change of absorption coefficient of biological tissues in laser induced interstitial thermotherapy
摘要
Abstract
The feasibility of real-time monitoring in laser induced interstitial thermotherapy (LITT) of biological tissues using near infrared spectrum technique is explored and validated. In vitro liver and rats with subcutantaneous implanted tumor models were chosen as experiment objects. Changes of absorption coefficient (μa) of tissue are real-time measured by near infrared spectrum system in laser induced interstitial thermotherapy. The result indicates that μa has some variations during LITT. The change law ofμa in vitro livers experiments is significant. It slowly goes up under low power, and rises greatly based on high power when biological tissues reach certain temperature(around 50℃). The change laws of μa during tumor experiments is different according to characteristics of tumor tissue which can be used for future clinical treatment. Experimental results show thatμa has valuable reference as a real-time monitoring factor in LITT of entity organizations, but it also needs further study as evaluating factor of the tumor treatment appraisal.关键词
医用光学与生物技术/激光诱导间质热疗/近红外光谱技术/吸收系数/实时监测Key words
medical optics and biotechnology/ laser induced interstitial thermotherapy/ near infrared spectrum technique/ absorption coefficient/ real-time monitoring分类
信息技术与安全科学引用本文复制引用
王晋阳,钱志余,钱爱平,吕操君,王栋,花国然..激光诱导间质热疗中生物组织吸收系数变化特性研究[J].量子电子学报,2011,28(1):91-95,5.基金项目
高等学校博士学科点专项科研基金(20103218110022)、江苏省自然科学基金(BK2008184)资助项目 （20103218110022）
