日用化学工业2011，Vol.41Issue(1)：73-75,3.
高效液相色谱法测定化妆品中苯扎溴铵
Determination of benzalkonium bromide in cosmetics by HPLC
摘要
Abstract
A HPLC method for determination of benzalkonium bromide in cosmetics was established.The sample was ultrasonic extracted with methanol (containing φ =0.5％ formic acid).The HPLC separation was carried out on a CAPCELL PAK SCX column (4.6 mm × 150 mm,5 μm) with mobile phase of 40 mmol/L ammonium acetate solution ( containing φ = 0.1％ triethylamine) and acetonitrile with gradient elution.The flow rate was 1.0 mL/min.The detecting wavelength was 215 nm.The column temperature was 25 ℃ ,and the injection volume was 10 μL.The limit of detection was 50 mg/kg.The linear plots were obtained between 5.0 μg/mL and 200.0 μg/mL.Overall recoveries were between 92.4％ and 97.3％ with RSD values between 3.41％ and 6.56％.关键词
化妆品/高效液相色谱法/苯扎溴铵Key words
cosmetics/ HPLC/ benzalkonium bromide分类
化学化工引用本文复制引用
刘艳琴,王浩,杨红梅,史海良,郭启雷..高效液相色谱法测定化妆品中苯扎溴铵[J].日用化学工业,2011,41(1):73-75,3.基金项目
国家质检总局质检公益性行业科研专项资助项目(200910267-02) （200910267-02）
