医药导报2011，Vol.30Issue(2)：193-196,4.DOI:10.3870/yydb.2011.02.017
荜澄茄超临界二氧化碳萃取提取物的药效学研究
Pharmacodynamic Study on Supercritical CO2 Extract from Fructus Litseae
汤杰 1万进 1施春阳1
作者信息
- 1. 华中科技大学同济医学院附属同济医院药学部,武汉,430030
- 折叠
摘要
Abstract
Objective To extract the volatile components from Fructus Litseae with a supercritical CO2 extraction technique and observe its pharmacodynamic activity. Methods The sensitivity of extracts from Fructus Litseae against Staphylococcus aureus and Pseudomonas aeruginosa was determined with an agar diffusion method. Its anti-inflammation effect was studied by measuring capillary permeability induced by intraperitoneal injection with acetic acid, swelling of the pinna in mice induced by xylene. Its analgesia effect was investigated in the murine pain models induced by chemical and physical stimulations. Results The bacteriostasis activity of the supercritical CO2 extracts from Fructus Litseae in vitro was confirmed. The extracts significantly inhibited two experimental animal inflammatory models and alleviated pain induced by acetic acid and fever. Conclusion It is preferable and reasonable to extract volatile components from Fructus Litseae, the extract of which is shown to have remarkable activity.关键词
荜澄茄/超临界二氧化碳萃取/抑菌/抗炎/镇痛分类
医药卫生引用本文复制引用
汤杰,万进,施春阳..荜澄茄超临界二氧化碳萃取提取物的药效学研究[J].医药导报,2011,30(2):193-196,4.
