烟台大学学报（自然科学与工程版）2011，Vol.24Issue(1)：59-64,6.
人参皂苷C-K急性毒性及其致肺水肿作用的研究
Acute Toxicity of Ginsenoside Compound K and Its Effect on Inducing Lung Edema
摘要
Abstract
Acute toxicity of ginsenoside compound K after intragastric administration and intravenous injection is investigated. Mice lung edema model is prepared by intravenous injection of ginsenoside compound K (100mg/kg) and the effects of adrenoceptor blocking pharmacons are observed. Mice lung edema model is duplicated by adnephrin induction and the effects of adrenoceptor blocking pharmacons are observed . The results indicates that the maximum dose of ginsenoside compound K to mice by intragastric administration is 10.0 g/kg.The half lethal dose ( LD50) with 95％ confidence interval of intravenous injection once to mice is 106.942mg/kg ( 96. 235 - 118. 449 mg/kg). The a-adrenoceptor blocking pharmacon can abate the lung edema induced by ginsenoside compound K while the β-adrenoceptor blocking pharmacon can aggravate it. The lung edema of mice induced by Ginsenoside compound K (100 mg/kg) is similar with that induced by adnephrin.关键词
人参皂苷C-K/肺水肿/肾上腺素受体/肾上腺素分类
医药卫生引用本文复制引用
刘汉清,陈方芳,苗宁舒,刘志峰..人参皂苷C-K急性毒性及其致肺水肿作用的研究[J].烟台大学学报（自然科学与工程版）,2011,24(1):59-64,6.基金项目
山东省科学仪器设备升级改造技术项目(2007GG10002026). （2007GG10002026）
