首页|期刊导航|中国神经再生研究（英文版）|Xuefuzhuyu injection induces neuronal differentiation of rat bone morrow mesenchymal stem cells
中国神经再生研究（英文版）2011，Vol.6Issue(3)：177-182,6.DOI:10.3969/j.issn.1673-5374.2011.03.003
Xuefuzhuyu injection induces neuronal differentiation of rat bone morrow mesenchymal stem cells
Xuefuzhuyu injection induces neuronal differentiation of rat bone morrow mesenchymal stem cells
摘要
Abstract
The primary effective components of Xuefuzhuyu, including Rhizoma Chqanxiong, Radix Salviae Miltiorrhiae, and RadixAnge/icae Sinensis, have been shown to induce the differentiation of bone marrow mesenchymal stern cells (BMMSCs) into neuronal-like cells.However, there is little available evidence on the effects of the Chinese herbal compound Xuefuzhuyu on BMMSC differentiation.The present study investigated the effects of Xuefuzhuyu on differentiation of rat BMMSCs into neuronal-like cells, and evaluated the optimal concentration for inducing differentiation.Inverted microscopy was used to observe BMMSCs induced by Xuefuzhuyu;immunocytochemistry revealed expression of the neuronal marker neuron-specific enolase surface antigen in the majority of BMMSCs following treatment with Xuefu2huyuat concentrations of 1,3, 5,and 10 g/L.A concentration of 3 g/L resulted in highest neuron-specific enolase expression.These results suggest that BMMSCs can be induced to differentiate into neuronal-like cells with Xuefuzhuyu, and 3 g/L is the optimal inductive concentration for effective differentiation.关键词
Xuefuzhuyu/bone marrow mesenchymal stem cells/neuronal-like cells/neural regeneration/induction/differentiationKey words
Xuefuzhuyu/bone marrow mesenchymal stem cells/neuronal-like cells/neural regeneration/induction/differentiation引用本文复制引用
Yanqing Yin,Bing Chen,Junlong Ke,Wei Mo,Xinhui Zou,Yuansheng Liang..Xuefuzhuyu injection induces neuronal differentiation of rat bone morrow mesenchymal stem cells[J].中国神经再生研究（英文版）,2011,6(3):177-182,6.基金项目
This work was funded by the Youth Science Foundation of Affiliated Hospital of Guangdong Medical College,No.2009k08. （）
