中国人兽共患病学报2011，Vol.27Issue(2)：120-123,4.
克拉霉素联合噻托溴胺治疗慢性阻塞性肺疾病(COPD)疗效
Clinical efficacy and value of clarithromycin with tiotropium for curing COPD
胡志雄 1周海英 1张熙 1余竹元2
作者信息
- 1. 复旦大学附属金山医院呼吸内科,上海,200540
- 2. 复旦大学附属中山医院,上海,200032
- 折叠
摘要
Abstract
In order to conduct an observation on efficacy and changes in lung function of clarithromycin with tiotropium for curing COPD, 61 patients were infected with Chlamydia pneumoniae(Cpn) in the 101 eligible patients with COPD. Total 101 COPD patients were randomized into two groups: Tio group (tiotropium, Tio) and CT group (clarithromycin + tiotropium, CT). Antibody against C. pneumoniae were measured using MIF technique and rapid quantitation of C-reactive protein (CRP) was measured by DIGFA method. After treatment, the patient's clinical symptoms of two groups were improved markedly (P＜0.05 for Tio group; P＜0. 001 for CT group),and FEV1/FVC (％) increased significantly (P＜0.05 in Tio group, P＜0.01 in CT group). The CRP levels decreased significantly in both groups(P＜0.05), while the CT group was more remarkable than the Tio group (P=0. 0000 and P=0. 0134, respectively). The positive rates of Cpn-IgM were down significantly only in CT group (P= 0. 001 ). The result would be better in combined therapy of clarithromycin with tiotropium for curing COPD, so CT group regime is deserved to be expanded.关键词
慢性阻塞性肺疾病(COPD)/克拉霉素/噻托溴胺/肺炎衣原体(Cpn)/C-反应蛋白(CRP)分类
医药卫生引用本文复制引用
胡志雄,周海英,张熙,余竹元..克拉霉素联合噻托溴胺治疗慢性阻塞性肺疾病(COPD)疗效[J].中国人兽共患病学报,2011,27(2):120-123,4.
