实验动物与比较医学2011，Vol.31Issue(1)：11-15,5.DOI:10.3969/j.issn.1674-5817.2011.01.003
大鼠大脑中动脉梗塞模型的同步辐射活体血管影像学研究
Application of Synchrotron Radiation Microangiography on Rat Middle Cerebral Artery Occlusion Models
摘要
Abstract
Objective To apply synchrotron radiation microangiography on the study of rat middle cerebral artery occlusion (MCAO) models. Method Twenty Sprague-Dawley rats weighing 300-350 g were divided into two groups: 4-0 suture group and 4-0 silicone-coated suture group. Immediately after MCAO surgery, synchrotron radiation angiography was conducted. Result The plain 4-0 nylon suture failed to completely occlude the middle cerebral artery (MCA) of the rat. There was still blood supply from anterior cerebral artery (ACA) and interior carotid artery (ICA). The silicone-coated 4-0 nylon suture successfully induced rat MCAO with 10％ rats had fenestrated MCAs (2/20).The variants in these rats were occluded when the suture depth was 17 mm. Conclusion The silicone-coated 4-0 nylone suture successfully induced MCAO in rats weighing from 300 to 350 g, and the plain 4-0 suture was not able to induce complete ischemia in these rats. Synchrotron radiation microagiography is useful for studying rat MCAO models and evaluating rat cerebral abnormalities.关键词
血管造影/缺血模型/大鼠/同步辐射分类
生物科学引用本文复制引用
袁法磊,管永靖,肖体乔,谢红兰,杨国源,王永亭..大鼠大脑中动脉梗塞模型的同步辐射活体血管影像学研究[J].实验动物与比较医学,2011,31(1):11-15,5.基金项目
国家重点基础研究发展计划(973计划)(2010CB834306) （973计划）
上海市科委实验动物研究专项(课题编号09140902400) （课题编号09140902400）
上海交通大学SMC-晨星青年学者奖计划 （）
