中国药理学与毒理学杂志2011，Vol.25Issue(1)：57-61,5.DOI:10.3867/j.issn.1000-3002.2011.01.011
阿司匹林丁香酚酯的抗炎作用及其可能的作用机制
Anti-inflammatory effects of aspirin eugenol ester and the potential mechanism
摘要
Abstract
OBJECTIVE To investigate anti-inflammation of aspirin eugenol ester (AEE)and its possible mechanism. METHODS Mice were divided into 4 groups: aspirin 0.2 g· kg-1,eugenol 0.18 g· kg-1, AEE 0. 18 and 0.36 g·kg-1 groups, and were ig administered with corresponding drug once daily for 3 d. Anti-inflammation of AEE was investigated with xylene induced ear swelling model, acetic acid induced peritoneal capillary permeability increase model, carrageenan induced hind paw edema model, and cotton ball induced granuloma of subcutaneous tissue model. The content of nitric oxide (NO) in serum, prostaglandin E2 ( PGE2 ), malondialdehyde (MDA) and 5-hydroxytryptamine (5-HT) in the paw was measured. RESULTS In the xylene induced ear swelling test, compared to model control group (7.0 ± 1.2) mg, the ear swelling degree decreased to3.9 ±1.2, 4.7 ±1.9, 3.9 ±1.9 and (3.8 ±1.1)mg in aspirin, eugenol, AEE0.18 and 0.36 g· kg-1 (P ＜ 0.05, P ＜ 0.01 ), respectively. Experiment results of abdominal capillary permeability of mice showed that aspirin, AEE 0. 18 and 0.36 g·kg-1 inhibited coeliac capillary permeability. The Evans blue effusion (A590nm ) was 0.29 ± 0.15, 0.34 ± 0.12 and 0.35 ± 0.18,respectively( P ＜0.05, P ＜0.01 ). The A590 nm of model control group was 0.56 ± 0.11. In cotton ball induced granuloma of subcutaneous tissue test, the content of granulomas of model control, aspirin, eugenol, AEE 0.18 and 0.36 g·kg- 1 groups was 12.5 ± 2.4, 7.0 ± 2.1,9.0 ± 1.7, 9.9 ±1.4 and ( 8.8 ± 1.8 )mg ( P ＜ 0.01 ). The result of carrageenan induced hind paw edema test showed that AEE 0. 18 g·kg -1 lightened the paw swelling and reduced significantly the level of PGE2 and 5-HT in the inflammatory paw tissue and NO in serum; this anti-inflammatory activity was similar to or stronger than that of aspirin and eugenol. CONCLUSION AEE has a similar anti-inflammation effect similar with aspirin and eugenol, and the mechanism may be related to its decrease in the content of PGE2, 5-HT in the phlogistic tissues and NO in serum.关键词
阿司匹林/丁香酚/阿司匹林丁香酚酯/炎症分类
医药卫生引用本文复制引用
李剑勇,王棋文,于远光,杨亚军,牛建荣,周旭正,张继瑜,魏小娟,李冰..阿司匹林丁香酚酯的抗炎作用及其可能的作用机制[J].中国药理学与毒理学杂志,2011,25(1):57-61,5.基金项目
中央级公益性科研院所基本科研业务费专项资金项目(BRF060403) （BRF060403）
甘肃省支撑计划项目(0804NKCA074) （0804NKCA074）
