中国药理学与毒理学杂志2011，Vol.25Issue(1)：102-105,4.DOI:10.3867/j.issn.1000-3002.2011.01.020
氧化应激致PC12细胞凋亡的信号传导途径的研究进展
Progress in signal pathways of apoptosis in PC12 cells induced by oxidative stress
杨静 1陈赛贞 1王婷2
作者信息
- 1. 台州市中心医院药剂科,浙江,台州,318000
- 2. 台州医院药剂科,浙江,台州,317000
- 折叠
摘要
Abstract
PC12 cells are widely used to study the function, differentiation and apoptosis of neurons and neurosecretory cells, as well as the secretion of neurotransmitters and the underlying molecular mechanisms. It is well known that oxidative stress can induce apoptosis of PC12 cells by activating multiple intracellular signal transduction pathways, including mitogen activated protein kinases, mitochondrial apoptosis and NF-κB pathways. This paper review signal pathways of apoptosis in PC12 cells induced by oxidative stress, and provids some reference for the treatment of antioxidants and interventional medicine of signal pathways of apoptosis against various nervous system diseases resulting from oxidative stress.关键词
氧化应激/PC12细胞/细胞凋亡分类
医药卫生引用本文复制引用
杨静,陈赛贞,王婷..氧化应激致PC12细胞凋亡的信号传导途径的研究进展[J].中国药理学与毒理学杂志,2011,25(1):102-105,4.
