中国药理学与毒理学杂志2011，Vol.25Issue(1)：93-96,4.DOI:10.3867/j.issn.1000-3002.2011.01.018
大电导钙激活钾通道对平滑肌的调控作用研究进展
Progress in regulation of large-conductance calcium-activated potassium channels on smooth muscle
李汉高 1李芳萍 2张雪梅2
作者信息
- 1. 潍坊医学院附属医院药剂科,山东,潍坊,261031
- 2. 复旦大学药学院药理学教研室,上海,201203
- 折叠
摘要
Abstract
Potassium channels are important to distribute in almost each tissue and implicated with many functions of cells, such as the formation of action potential and signal transduction. Large-conductance calcium-activated potassium channel ( BKca/Maxi K) is one of the potassium channels and expressed in many types of cells. The activation of BKca/Maxi K is able to induce the hyperpolarization of plasma membrane and the inhibition of voltagedependent calcium channel activity. So BKca/Maxi K plays an important role in the relaxation of smooth muscle.The pathogenesis of many diseases is also involved in activation and inactivation, expression, or mutation of this potassium channel. BKca/Maxi K participates in the regulation of cardiovascular smooth muscle, myometrial smooth muscle, smooth muscle in the airway and penile erection. Especially, the gene therapy of BKca/Maxi K to erectile dysfunction enjoys some advantages over medication.关键词
大电导钙激活钾通道/平滑肌,心血管/平滑肌,子宫/勃起障碍/呼吸道分类
医药卫生引用本文复制引用
李汉高,李芳萍,张雪梅..大电导钙激活钾通道对平滑肌的调控作用研究进展[J].中国药理学与毒理学杂志,2011,25(1):93-96,4.
