中国中西医结合杂志2011，Vol.31Issue(2)：177-181,5.
基于SIMCA法的肝炎后肝硬化中医证候判别研究
Study on Chinese Medical Syndrome Identification in Patients with Post-hepatitis Cirrhosis by Soft Independent Modeling of Class Analogy
摘要
Abstract
Objective To explore the feasibility of Chinese medical syndrome identification in patients with post-hepatitis cirrhosis (PHC) by soft independent modeling of class analogy (SIMCA). Methods After variants were normalized, SIMCA was used to analyze clinical symptoms, physical signs, and biological parameters in 268 PHC patients, and the obtained distance of SIMCA was used to identify the syndromes of PHC. Some incorrect reasons were then tested by Mann-Whitney test. Results The recognition rates of 5 Chinese medical syndromes (Gan depression and Pi deficiency syndrome, Gan-Shen yin-deficiency syndrome, Pi-Shen yang-deficiency syndrome, inner accumulation of dampness-heat syndrome, and stasis-heat accumulation syndrome) were 72. 39％ in the nearest class, and 17. 91％ in the sub-near class, as well as the total recognition rate was 90. 3％. The highest recognition rate (95. 24％ ) presented in the recognition on Gan-Shen yin-deficiency syndrome. Among some vital symptom variants of nearest class, significant difference could be found between identified and un-identified syndromes ( P ＜0.05). Conclusion Identification of Chinese medical syndromes by SIMCA has rather higher goodness-of-fit with clinical practice, to set up a SIMCA depended syndrome identifying system could offer a useful reference for Chinese medical syndrome identification.关键词
SIMCA法/肝炎后肝硬化/证候/症状/生物学指标引用本文复制引用
张华,苏越,王磊,张琴,苏式兵,刘平..基于SIMCA法的肝炎后肝硬化中医证候判别研究[J].中国中西医结合杂志,2011,31(2):177-181,5.基金项目
中国博士后基金资助项目(No.20070420106) （No.20070420106）
国家重点基础研究发展计划(973计划)资助项目(No.2006CB504801) （973计划）
上海市重点学科建设项目资助(No.Y0302) （No.Y0302）
上海市教育委员会E-研究院建设计划资助项目(No.E03008) （No.E03008）
上海市教育委员会高校高水平特色发展项目--中医复杂系统研究(上海市教委财2005-81) （上海市教委财2005-81）
