中国中西医结合杂志2011，Vol.31Issue(2)：168-171,4.
加味藿朴夏苓汤对脾胃湿热证临床疗效及舌上皮细胞凋亡的影响
Effect of Modified Huopo Xialing Decoction in Treating Pi-Wei Dampness-heat Syndrome and Its Impact on the Tongue Epithelial Cell Apoptosis
摘要
Abstract
Objective To study the effects of modified Huopo Xialing Decoction (HXD) in treating patients of Pi-Wei dampness-heat syndrome ( PWDHS ) and its impact on epithelial cell apoptosis of tongue.Methods Fifty patients with PWDHD were randomized depending on their visiting sequence into two groups, the 30 patients in the treatment group treated with HXD and the 20 in the control group treated with Domperidone.The therapeutic course for both groups was 2 weeks.Besides, a normal control group consisting of 30 healthy volunteers was set up.The changes of tongue fur, grade of major syndromes in different groups were observed and scored before and after treatment to evaluate the therapeutic effectiveness, and the apoptotic index ( AI ) was estimated using TUNEL technique.Results AI in the two patient groups before treatment was obviously lower than that in the normal group ( P＜0.01 or P＜0.05); after treatment, AI in the treatment group increased significantly ( P＜0.01 ), with no difference from that in the normal group ( P＞0.05), while in the control group, it only showed a slight trend of increasing.Similar outcome of tongue fur grades was seen in the two groups, it was improved significantly (P ＜0.01 ) in the treatment group but insignificantly in the control group (P ＞ 0.05).After treatment, syndrome scoers were both lower in the two groups ( P ＜0.01 ), but the decrement in the treatment group was more significant than that in the control group ( P ＜ 0.01 ).Comparison between groups showed that the total effective rate in the treatment group was significantly superior to that in the control group (90％ vs 65％,P＜0.01 ).Conclusion HXD has good clinical efficacy in treating PWDHS, and has good effect in alleviating the greasy yellow tongue fur in patients with PWDHS by accelerating the tongue epithelial cell apoptosis.关键词
加味藿朴夏苓汤/脾胃湿热证/细胞凋亡引用本文复制引用
卓冬婷,吕军影,黄李平,阙铁生,李佳荃..加味藿朴夏苓汤对脾胃湿热证临床疗效及舌上皮细胞凋亡的影响[J].中国中西医结合杂志,2011,31(2):168-171,4.基金项目
广西壮族自治区卫生厅立项课题(No. Z2008103) （No. Z2008103）
广西自然科学基金课题(No. 桂科自0447062) （No. 桂科自0447062）
