中国实用内科杂志2011，Vol.31Issue(2)：122-124,3.
药物致急性间质性肾炎的临床及病理特征
Clinical and pathological features of drug induced acute interstitial nephritis
陈冬梅 1唐政 1罗春雷 1周岩 1陈惠萍 1曾彩虹 1刘志红1
作者信息
- 1. 南京大学医学院南京军区南京总医院,全军肾脏病研究所,南京,210002
- 折叠
摘要
Abstract
Objective To investigate the clinical and pathological features of drug-induced acute interstitial nephritis (DAIN). Methods Seventy-two patients with DAIN(confirmed by biopsy from January 2003 to December 2009)were divided into two groups. Group 1 :serum creatinine (Scr) level dropped to the baseline within 3 months;Group 2:renal dysfunction continued for more than 3 months. Clinical and pathological features were compared between the two groups. Results Antibiotics (61.1％) were the main cause of DAIN, followed by the NSAIDs ( 22. 2％ ). Most patients had alimentary symptoms. The average age of patients was much higher in group 2. Patients in group 1 presented with more oliguria and less asymptom compared with those in group 2. As for the pathology, more severe renal interstitial inflammatory cell infiltrations were observed in group 2. Conclusion Antiboitics are the main offending drugs causing DAIN. Elder age and the renal interstitial inflammatory cell infiltration can lead to delayed renal function recovery and chronic interstitial nephritis.关键词
急性间质性肾炎/临床病理分类
医药卫生引用本文复制引用
陈冬梅,唐政,罗春雷,周岩,陈惠萍,曾彩虹,刘志红..药物致急性间质性肾炎的临床及病理特征[J].中国实用内科杂志,2011,31(2):122-124,3.
