临床肝胆病杂志2011，Vol.27Issue(2)：143-144,156,3.
替比夫定和拉米夫定治疗慢性乙型肝炎对肌酸激酶的影响
The study of the change in creatine kinase in patients with chronic hepatitis B during the antiviral treatment with Telbivudine and Lamivudine
金清龙 1王中峰 1闫红青 1牛俊奇1
作者信息
- 1. 吉林大学第一医院肝胆胰内科,长春,130021
- 折叠
摘要
Abstract
Objective To compare the impact of creatine kinase (CK) on telbivudine and lamivudine in antiviral treatment.Methods 52 patients participated in 015 study and 007 study were randomly divided into two treatment groups assigned with telbivudine 600 mg daily and lamivudine 100 mg daily for 104 weeks respectively. CK elevation and clinical symptoms were observed in the two treatment groups at different peroids. Results CK elevation was observed in the two treatment groups, and the frequency was higher in telbivudine than that in lamivudine (76％ vs 44.4％).There was no symptom observed in the patients with CK elevation. Conclusion CK elevation is common in nucleoside analogue antiviral therapy. CK elevation frequency in telbivudine treatment groups was higher. Majority achieved grade 1-2 CK level elevation(1-7 ×ULN). The cause of CK elevation was not induced by myocardial injury. All the patients had no symptoms. CK elevation in patients was transient and resolved without treatment.关键词
肝炎,乙型,慢性/替比夫定/拉米夫定/肌酸激酶Key words
hepatitis B, chronic/ Telbivudine/ Lamivudine/ creatine kinase分类
医药卫生引用本文复制引用
金清龙,王中峰,闫红青,牛俊奇..替比夫定和拉米夫定治疗慢性乙型肝炎对肌酸激酶的影响[J].临床肝胆病杂志,2011,27(2):143-144,156,3.
