中国药房2011，Vol.22Issue(8)：695-697,3.
甲钴胺注射液治疗2型糖尿病并发脑梗死患者的临床疗效观察
Investigation of Clinical Efficacy and Mechanism of Methylcobalamin Injection in the Treatment of Type 2 Diabetes Mellitus Patients with Cerebral Infarction
黄文清 1范小艳 1刘景辉 1陈惠琼1
作者信息
- 1. 广东佛山市第一人民医院康复科,佛山市,528000
- 折叠
摘要
Abstract
OBJECTIVE: To study the clinical efficacy and mechanism of Methylcobalamin injection for type 2 diabetes mellitus patients with cerebral infarction.METHODS: 78 type 2 diabetes mellitus patients with cerebral infarction were randomly divided into Methylcobalamin injection therapy group and control group.Both groups were given conventional treatment, such as anti-platelet aggregation, cerebral circulation improvement and neurotrophy.Early rehabilitation therapy was given according to illness condition and neurological impairment.Therapy group received intravenous injection of Methylcobalamin injection (2 000 μg· d-1) once a day for 4 weeks.Before and after treatment, neurological function and activities of daily living (ADL) were evaluated by ESS and Barthel index.The level of Hcy in plasma was also determined.RESULTS: There was no significant difference in ESS score, Barthel index and Hcy level in 2 groups before treatment.After 4 week treatment, ESS score and Bartbel index in 2 groups increased significantly (P＜0.05), and that of Methylcobalamin injection therapy group was significantly higher than that of control group (P＜0.05).The Hcy levels in plasma decreased significantly in both groups after treatment (P＜0.05), but that of Methylcobalamin injection therapy group was significantly lower than that of control group (P＜0.05).CONCLUSION: Methylcobalamin injection therapy can improve clinical prognosis in type 2 diabetes mellitus patients with acute cerebral infarction, which maybe related with the decrease of Hcy level in plasma.关键词
糖尿病/脑梗死/同型半胱氨酸/甲钴胺分类
医药卫生引用本文复制引用
黄文清,范小艳,刘景辉,陈惠琼..甲钴胺注射液治疗2型糖尿病并发脑梗死患者的临床疗效观察[J].中国药房,2011,22(8):695-697,3.
