实用肿瘤杂志2011，Vol.26Issue(1)：17-21,5.
p53Arg72Pro多态性与细胞周期调控蛋白在HPV相关子宫颈鳞癌中的表达及意义
Study on correlation between expression of cell cycle regulation protein and p53Arg72Pro polymorphisms in HPV-associated cervical cancer
摘要
Abstract
Objective To study the role of inactivation of p53Arg protein and p53Pro protein and aberrant regulation of cell cycle in the mechanism of HPV - related cervical cancer.Methods The expression of CyclinDl, Cdk4, phosphorylation of Rb and Ki-67 (PI) were detected by immunohistochemistry.Results The expressions of CyclinD1, Cdk4, high phosphorylation rate of Rb and PI values in cervical cancer of p53 negative group were higher than those in the control group (x2 = 16.878, P ＜ 0.01 ;x2 = 21.120, P ＜ 0.01 ;x2= 40.36, P ＜ 0.01; t = 30.53, P ＜ 0.01 ).The expressions of CyclinD1 and Cdk4, phosphorylation of Rb showed a positive correlation( P ＜ 0.01 ).The PI values in phosphorylation Rb positive group was higher than that in the negative group( P ＜ 0.05).The expression of CyclinD1 and PI values of p53Pro genotype were higher than those of the p53Arg and p53Pro/Arg genotype ( P ＜ 0.05).Conclusions HPV positive cervical cancer shows part of p53 protein are negatively expressed, which indicates that the p53 protein is degraded by E6 protein.The high PI values in the p53 protein negatively expressed cervical cancer tissues is related to the CyclinD1-Cdk4-Rb pathway.p53Pro protein has stronger abiliy to arrest cell cycle than p53Arg protein.关键词
宫颈肿瘤/乳头状瘤病毒,人/细胞周期蛋白质类/p53Arg72Pro/免疫组织化学分类
医药卫生引用本文复制引用
杨安强,严丽华,米开热木,贾薇,陶林,潘晓琳..p53Arg72Pro多态性与细胞周期调控蛋白在HPV相关子宫颈鳞癌中的表达及意义 [J].实用肿瘤杂志,2011,26(1):17-21,5.基金项目
国家自然科学基金资助项目(30560046) （30560046）
