实用临床医药杂志2011，Vol.15Issue(1)：62-66,5.
鼻咽癌调强适形放疗中正常器官体积剂量变化的研究
Changes of volume dose of normal organs in IMRT for nasopharyngeal carcinoma
王震吾 1王明智 1杨波 1楚建军1
作者信息
- 1. 苏州大学附属第四医院,肿瘤放疗科,江苏,无锡,214062
- 折叠
摘要
Abstract
Objective To investigate the changes of the volume dose of normal organs in intensity modulated radiotherapy for nasopharyngeal carcinoma through repeated CT imaging and replanning. Methods This study enrolled twenty patients with nasopharyngeal carcinoma who were treated by intensity modulated radiotherapy(IMRT) as the first-line treatment, nasopharynx, cervical part and supraclavicular region were all treated by IMRT; we designed the first IMRT plan (planl)and formed DVH1. CT-simulated image was rebuilt at the same body position at the twentieth time during radiotherapy, and planl was copied to the second CT-simulated image and generated planl-2 and DVH1-2. we redesigned the second CT-simulated image and formed plan2, The data obtained from CT-simulated image and DVH were analyzed terms of in the vanations of normal organ volume dose between before and the twentieth treatment. Results The volume of plan1-2 about the left and right parotids were much decreased compared with planl ( P ＜ 0.05). The maximum dose, mean dose, D50 and V35 of parotid glands, the maximum dose, mean dose and Dlcc of spinal cord obviously increased(P＜0.05). There was statistical difference in the maximum dose of brain stem( P = 0.011 ); the parotid's augmented dose correlated with the shrunken degree of weight, left and right contour and parotids; and the maximum dose of spinal cord correlated with left and right contour( r = 0.469, P = 0.037); and other normal organs have no difference. Conclusion There were some changes of the normal organs volume dose in IMRT for nasopharyngeal carcinoma, especially for parotid glands. It was requisite to rebuild CT-simulated image and renew plan during midanaphase treatment to reduce radiated dosage and avoid radiotherapy reaction.关键词
鼻咽癌/调强适形放疗/剂量体积直方图分类
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王震吾,王明智,杨波,楚建军..鼻咽癌调强适形放疗中正常器官体积剂量变化的研究[J].实用临床医药杂志,2011,15(1):62-66,5.
