生物信息学2011，Vol.9Issue(1)：72-75,81,5.DOI:10.3969/j.issn.1672-5565.2011.01.018
小鼠EDNRB基因启动子生物信息学分析
Bioinformatics Analysis of Mouse EDNRB Gene Promoter Regions
摘要
Abstract
EDNRB/EDN3/ECE - 1 signaling pathway plays an important role in the differentiation and migration of neural crest cells to form ganglion cells during embryonic development. Online bioinformatics tools and phylogenetic foot printing were used to analyze Hirschsprung' s disease associated EDNRB gene ' s promoter. The results showed that mouse EDNRB gene was mapped to chromosome 14, which encoded a protein consisting of 442 amino acids with a molecular weight 49430Da. 300bp around transcriptional start site might be promoter regions, which included a CpG island with a length of 1473bp. The promoter regions had two conserved sequences, which contained 33 same transcriptional factor binding sites.关键词
EDNRB/启动子/生物信息学/转录因子分类
生物科学引用本文复制引用
张万里,李伟,吴川清,林学科,李航,王国斌,陶凯雄..小鼠EDNRB基因启动子生物信息学分析[J].生物信息学,2011,9(1):72-75,81,5.基金项目
国家自然科学基金资助项目(30872473). （30872473）
