实用临床医药杂志2011，Vol.15Issue(1)：101-103,3.
尼扎替丁分散片与尼扎替丁普通片在健康人体内的药代动力学研究
Pharmacokinetics comparison between nizatidine dispersible tablets and nizatidine conventional tablets in healthy volunteers
冒群1
作者信息
- 1. 江苏省如皋市人民医院,药剂科,江苏,如皋,226500
- 折叠
摘要
Abstract
Objective To compare the pharmacokinetics of nizatidine dispersible tablets and nizatidine conventional tablets in healthy volunteers. Methods 12 healthy male volunteers were divided into two groups, who received a single oral dose of 150 mg nizatidine dispersible tablets and nizatidine conventional tablets, respectively. The plasma concentrations of nizatidine were determined by HPLC, and the data was analyzed by using DAS 2.1. Results The main pharmacokinetic parameters of nizatidine dispersible tablets and nizatidine tablets were as follows: Cmax were (1614.8± 106.2) μg/L and (1 311.7±89.5) μg/L, tmax were(1.0±0.6) h and (1.5±0.4) h,t1/2 were (4.8 ± 1.3) h and (5.3 ± 1.1) h, AUC0∞ were (4 731.3 ± 118.29) μg/(h·L) and (4 518.6 ± 108.3) μg/(h· L); AUC0t were (2 216.7 ± 106.9) μg/(h· L) and (2 187.4 ± 78.9) μg/(h·L) respectively. Conclusions tmax and t1/2 of nizatidine dispersible tablets were significantly shorter than those of nizatidine conventional tablets, and Cmax of nizatidine dispersible tablets was significantly higher than that of nizatidine conventional tablets. It suggested that nizatidine dispersible tablets had a property of quick release.关键词
尼扎替丁/分散片/血药浓度/药代动力学分类
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冒群..尼扎替丁分散片与尼扎替丁普通片在健康人体内的药代动力学研究[J].实用临床医药杂志,2011,15(1):101-103,3.
