实用临床医药杂志2011，Vol.15Issue(1)：125-128,4.
CYP2C19基因多态性在江苏及其周边地区汉族人群的调查研究
A study on the distribution of CYP2C19 genetic polymorphism among Han Chinese in Jiangsu province
顾连云 1赵萍1
作者信息
- 1. 南京医科大学第一附属医院,江苏,南京,210029
- 折叠
摘要
Abstract
Objective To investigate distribution status of CYP450 2C19 genotype in Han healthy subjects in Jiangsu Province. Methods The CYP2C19 genotype of 81 Han healthy subjects were determined by the polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP). Results The frequency of CYP2C19 homozygous extensive metabolisms (homEMs), heterozygous extensive metabolisms (hetEMs) and poor metabolisms (PMs) in the 81 Chinese subjects was 38.3％, 45.7％ and 16.0％, respectively. Conclusion The frequency of CYP2C19 poor metabolisms coincides with its frequency of Chinese population.关键词
细胞色素P450/CYP2C19/遗传学多态性分类
医药卫生引用本文复制引用
顾连云,赵萍..CYP2C19基因多态性在江苏及其周边地区汉族人群的调查研究[J].实用临床医药杂志,2011,15(1):125-128,4.
