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左磷右胺盐母液黏度测定与关联

乔琳 谭蔚 崔波 刘瑶 董远达 刘丽艳

化学工程2011,Vol.39Issue(1):66-69,4.
化学工程2011,Vol.39Issue(1):66-69,4.

左磷右胺盐母液黏度测定与关联

Determination and correlation of mother liquor viscosity of R-( + ) -α-phenethylammonium. IR. 2S-(-)-cis-1, 2-epoxypropyl phosphonate

乔琳 1谭蔚 1崔波 2刘瑶 2董远达 2刘丽艳1

作者信息

  • 1. 天津大学,化工学院,天津,300072
  • 2. 东北制药总厂,辽宁,沈阳,110026
  • 折叠

摘要

Abstract

The mother liquor components and viscosity of R-( + )-α-phenethylammonium . IR. 2S-( - )-cis-1,2-epoxypropyl phosphonate were analyzed on the basis of the liquid mixtures viscosity theory. With the proper viscosity equations, the theoretical calculation formula of mother liquor viscosity of R-( + ) -α-phenethylammonium.IR. 2S-( - )-cis-l, 2-epoxypropyl phosphonate with ethanol or water was obtained. The calculated viscosity was compared with the experimental results. It shows that the theoretical viscosity calculation formula is well correlated with the systems containing a little water, but has some deviation with the system containing more water. The result also reveals that ethanol and a certain amount of water can efficiently reduce the viscosity of mother liquor, which supplies a simple and convenient way for engineering application in the chemical production of fosfomycin sodium.

关键词

母液/(±)2顺21,22环氧丙基磷酸(±)苯乙胺/黏度/磷霉素钠

Key words

mother liquor/ R-( + )-α-phenethylammonium. IR. 2S-( - )-cis-l, 2-epoxypropyl phosphonate/ viscosity/ fosfomycin sodium

分类

数理科学

引用本文复制引用

乔琳,谭蔚,崔波,刘瑶,董远达,刘丽艳..左磷右胺盐母液黏度测定与关联[J].化学工程,2011,39(1):66-69,4.

化学工程

OA北大核心CSCDCSTPCD

1005-9954

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