外科理论与实践2011，Vol.16Issue(1)：29-34,6.
MRI对浸润性乳腺癌新辅助化疗疗效的评估价值
Evaluation of the therapeutic effects of neoadjuvant chemotherapy in invasive breast cancer using magnetic resonance imaging
摘要
Abstract
Objective To explore the value of magnetic resonance imaging (MRI) in evaluating the therapeutic effects of neoadjuvant chemotherapy in invasive breast cancer. Methods Twenty cases of invasive breast cancers with MRI examination both before and after neoadjuvant chemotherapy were retrospectively analyzed. The pathological response was divided into 5 grades: grade 4 and 5 were referred to as major histological response (MHR). The imaging features of the cases were compared with this notation. All the images were reviewed by two radiologists using an interactive workstation in order to give a grading score with the reference of pathological grading system; they were required to consult a third experienced radiologist when they could not reach a consensus. Kappa test was performed for the comparison of the MRI and pathological outcome after surgery. Results The MRI diagnosis had a good correlation with the pathological results in evaluating the residual cancerous lesion after the neoadjuvant chemotherapy in invasive breast cancer (Kappa=0.6). The size of the lesion showed remarkable reduction after the treatment (P＜0.001). The time-signal intensity curve of the breast cancer changed greatly when comparing the pre-treatment data with that of the post-treatment (P=0.014). The mean of the apparent diffusion coefficient (ADC) value was 0.89±0.14×l0-3mm2/s before the new adjuvant chemotherapy while it rose higher to 1.13±0.31 ×l0-3mm2/s after the treatment, demonstrating a statistical significance (P=0.05).Conclusions Breast MRI is valuable in noninvasive evaluation of the therapeutic effects of neoadjuvant chemotherapy in invasive breast cancer. Thus, the breast MRI can be used to predict the postoperative pathologic response.关键词
乳腺癌/新辅助化疗/磁共振成像/病理学反应性/治疗疗效分类
医药卫生引用本文复制引用
胡静,李志,赵亚娥,汪登斌,沈坤炜,李亚芬,陈伟国,柴维敏,姜婷婷,王露岚..MRI对浸润性乳腺癌新辅助化疗疗效的评估价值[J].外科理论与实践,2011,16(1):29-34,6.基金项目
上海市科委创新行动计划纳米专项研究项目(0852nm04600) （0852nm04600）
上海市教育委员会科研创新重点项目(09zz112) （09zz112）
