外科理论与实践2011，Vol.16Issue(1)：49-53,5.
乳腺癌组织中血管内皮生长因子-C和人类表皮生长因子-2的表达及意义
Expression and clinical significance of VEGF-C and C-erbB-2 in breast cancer tissues
摘要
Abstract
Objective To investigate the expression of vascular endothelial growth factor-C (VEGF-C) and initial cancer gene (C-erbB-2) in breast cancer tissue as well as their relationship with clinical pathological characteristics.Methods lmmunohistochemical technique was used to detect the expression of VEGF-C and C-erbB-2 in 76 patients with breast cancer and 20 cases with benign breast lesions. Results A total of 72.37％ patients were found with positive expression of VEGF-C and 51.31％ patients with positive expression of C-erbB-2 in breast cancer tissues; in comparison to the positive expression rates in benign lesions, P＜0.05, there were statistically significant differences (P＜0.OI). The positive expression of VEGF-C and C-erbB-2 bore no correlation ship with the age of the patients, the tumor size and histological classification of the cancer (P＞O.05), and correlated positively with the lymph node metastasis (P＜0.05 or 0.01); VEGF-C correlated positively with the clinical staging (P＜O.05). The expression of VEGF-C in breast cancer correlated positively with the expression of C-erbB-2 (X2=7.031, P＜0.01). Conclusions VEGF-C and C-erbB-2 play an important role in the oneogenesis and development of breast cancer, VEGF-C and C-erbB-2 may be used as markers for clinically predicting the prognosis of breast cancer.关键词
乳腺肿瘤/血管内皮生长因子-C/人类表皮生长因子-2/免疫组织化学分类
医药卫生引用本文复制引用
王金卫,陈辉兵,辛剑,施亚香,陈逸韶,陈学荣..乳腺癌组织中血管内皮生长因子-C和人类表皮生长因子-2的表达及意义[J].外科理论与实践,2011,16(1):49-53,5.基金项目
台州市科技局科技计划项目(072KY25) （072KY25）
