外科理论与实践2011，Vol.16Issue(1)：45-48,4.
胸苷酸合成酶在乳腺癌中的表达及其与预后的关系
Expression level in thymidylate synthase in breast cancer and its correlation with prognosis
黄晓曦 1吴剑斌 1赵帅 1张智滔 1高凌云2
作者信息
- 1. 福建省妇幼保健院乳腺科,福建,福州,350001
- 2. 福建医科大学病理学系,福建,福州,350004
- 折叠
摘要
Abstract
Objective To study the expression level of thymidylate synthase in breast cancer, and to assess the feasibility of TS as an indicator to determine the sensibility towards 5-fluorouracil (5-FU) chemotherapy. Methods Application of S-P immunohistochemical method in detecting the expression of TS and its relationship with clinical pathological parameters between the 94 cases of breast cancer and 40 cases of non-cancerous diseases of the breast.Results ① The low expression rate of TS was 55.3％ (52/94),tbe high expression rate was 44.7％ (42/94); the expression rate was compared with that of the healthy control group, and demonstrated significant difference (P＜0.01).② With the increase of histopathological grading of the breast cancer, the expression level of TS concomitantly increase significantly. There existed a significant difference between the Ⅰ and Ⅲ grade levels (x2=17.8756,P＜0.01) ;there was no significant difference between the expression of TS and the age, tumor size, lymph node metastasis and TNM staging (P＞ 0.05). ③ The 5-year survival rate of the group with high expression of the TS was 26.5％, the group with low expression of TS was 58.7％. The survival time and the 5-year survival rate of the low TS expression group was higher than that of the high expression group, and there existed a statistically significant difference between the 2 groups (P＜0.05). Conclusions The expression of TS in breast cancer patients is closely related to their sensibility towards 5-FU chemotherapy the expression of TS could be used as an indicator to determine the sensitivity towards 5-FU chemotherapy and the prognosis of the patients.关键词
乳腺癌/胸苷酸合成酶/5-氟尿嘧啶/免疫组织化学分类
医药卫生引用本文复制引用
黄晓曦,吴剑斌,赵帅,张智滔,高凌云..胸苷酸合成酶在乳腺癌中的表达及其与预后的关系[J].外科理论与实践,2011,16(1):45-48,4.
