安徽医科大学学报2011，Vol.46Issue(2)：146-150,5.
游泳运动及二甲双胍对肥胖大鼠血清chemerin水平的影响
Effects of swimming exercise and metformin on serum chemerin level of high-fat-diet induced obesity rats
摘要
Abstract
Objective To investigate the effects of swimming exercise, mefformin and the combination of both interventions on serum chemerin levels of high-fat-diet induced obesity rats, and to explore the relationship between chemerin, and obesity-related metabolic disorders. Methods 70 SD rats were randomly divided into two groups in which 10 rats were fed with normal control diet as the NC group, and the remaining 60 were fed with high-fat-diet as the HD group. After 16 weeks obesity model( n = 40) was established from HD group and was randomly divided into four groups: high fat group ( HF), swimming group ( SWI ), mefformin group ( MET), and the combination of swimming and metformin group ( SWI + MET) with 10 rats in each group. Body weight ( BW), fasting blood glucose (FBG), fasting insulin ( FINS ), total cholesterol ( TCH ), triglyceride ( TG ), very low density lipoprotein ( VLDL ),HOMA-IR and fasting chemerin were detected before and after 6 weeks of treatment. Results ① After 16 weeks high fat diet induced obesity, compared with NC group, the levels of BW, FBG, FINS, TCH, TG, HOMA-IR and chemeirn in each group were increased significantly( P ＜ 0. 05 ). There were no statistical differences in the parameters among the four groups of the obesity model ( P ＞ 0. 05 ). ② After 6 weeks intervention, compared with HF group, the levels of BW, FBG, FINS, TCH, TG, VLDL, HOMA-IR and chemerin in SWI group, MET group and SWI + MET group were down-regulated ( P ＜ 0. 05 ), but the parameters showed no difference among the three intervention groups( P ＞ 0. 05 ). ③ The level of FINS correlated independently with that of chemerin regardless of before or after intervention( P ＜ 0. 05 ). Conclusion High fat diet can induce SD rats obesity and also increase the levels of chemerin. Swimming,metformin and the combination of both intervention can decrease the level of chemerin and improve metabolic disorders remarkably in obesity rats. Chemerin maybe a key participant element in the etiology and pathophysiology of obesity-related metabolic disorders.关键词
肥胖症/二甲双胍/疾病模型,动物/游泳Key words
obesity/ metformin/ disease models, animal/ swimming分类
医药卫生引用本文复制引用
刘燕,王长江,代芳,胡红琳,夏莉..游泳运动及二甲双胍对肥胖大鼠血清chemerin水平的影响[J].安徽医科大学学报,2011,46(2):146-150,5.基金项目
安徽省教育厅自然科学重点项目(编号:KJ2009 B047Z) （编号:KJ2009 B047Z）
安徽省卫生厅科研基金(编号:09A018) （编号:09A018）
