安徽医科大学学报2011，Vol.46Issue(3)：261-264,4.
系统性红斑狼疮患者血清干扰素诱导蛋白10的表达水平及临床意义
Serum level of interferon-inducible protein 10 and its clinical significance in patients with systemic lupus erythematosus
摘要
Abstract
Objective To explore the expression level of interferon-inducible protein 10(IP-10) and its clinical diagnostic significance in patients with systemic lupus erythematosus(SLE). Methods Using ELISA to detect the serum expression level of IP-10 in 96 patiens with SLE and 30 healthy controls. The relationship between the activity of the pathogenetic condition( SLEDAI score ), anti-dS DNA antibody, anti-Cl q antibody, complement C3, C4, hsCRP,24 h urine protein quantitation (24 h UPQ), ESR and serum IP-10 level were analyzed. To distinguish the effect of IP-10 in the regulation of inflammatory immune response by detecting IFN-γof Thl cytokines and IL-4 of Th2 cytokines. Results The overall levels of serum IP-10 in SLE patients increased markedly than that in normal control group. IP-10 levels in the active lupus nephritis patients were obviously higher than that in active no-renal involvement group and stabilization patients( P ＜0. 01 ). However,IP-10 levels in active no-renal involvement group had no statistical significance with stabilization lupus nephritis patients. In the active patients, the level of serum IP10 showed significant positive correlations with SLEDAI, dS-DNA, hs-CRP and negative correlation with serum C3 level(P ＜0. 01 )and no correlation with C4,24 h UPQ,ESR,but in the renal involvement patients,no matter how the patients lie in active or in stabilization stage. The level of serum IP-10 showed significant positive correlations with C1 q( P ＜0. 05 ). The levels of serum IFN-γ, IL-4 in SLE patients was increased markedly than that in normal control group. In the active and stabilization patients, the level of IP-10 all showed significant correlations with IFNγ and IL-4/IFN-y(P ＜0. 01 ). The level of IP-10 only showed significant correlations with IL-4 in stabilization patients( P ＜0. 01 ). Conclusion IP-10 plays an important role in the diagnosis and early monitor of the activity of SLE, especially in the patients with lupus nephritis by mediating the inflammatory immune response of Thl.关键词
红斑狼疮,系统性/趋化因子CXCL10/细胞因子类Key words
lupus erythematosus, systemic/ chemokine CXCL10 /cytokines分类
医药卫生引用本文复制引用
张铭明,夏丹,唐婷婷,徐建华,沙泉..系统性红斑狼疮患者血清干扰素诱导蛋白10的表达水平及临床意义[J].安徽医科大学学报,2011,46(3):261-264,4.基金项目
安徽省优秀青年科技基金(编号:04043053) （编号:04043053）
教育部留学回国人员科研启动基金(编号:2005383) （编号:2005383）
安徽高校省级自然科学研究重点项目(编号:KJ2007A023) （编号:KJ2007A023）
