安徽医科大学学报2011，Vol.46Issue(3)：245-248,4.
抗癌平颗粒剂的体内外抗肿瘤作用
Experimental study of antitumor effect of Kang'aiping granule in vivo and in vitro
胡宗涛 1魏倩 2董六一2
作者信息
- 1. 安徽医科大学解放军临床学院(解放军105医院)肿瘤中心,合肥,230031
- 2. 安徽医科大学药理学教研室、抗炎免疫药理学省部共建教育部重点实验室、国家中医药管理局中药药理三级实验室,合肥,230032
- 折叠
摘要
Abstract
Objective To investigate the anticancer effect of Kang'aiping granule in vivo and in vitro. Methods Mice bearing transplanted tumor S180 and EAC were used to study the anticancer effects of Kang'aiping granule.Strengthening body resistance test was employed to observe the immune function of Kang'aiping granule on mice S180. MTT assay was used to assess the viability of BGC-823 cell treated with different concentrations of Kangaiping granule. Results Kang'aiping granule obviously inhibited the growth of transplanted tumor S180 and EAC in vivo.Kang'aiping granule (0. 5 g/kg) combined with small-dose cyclophosphamide(5,10 mg/kg) could increase the inhibition rate of tumor S180. Kang'aiping granule (0. 5,1,2 g/kg) combined with high-dose cyclophosphamide (80 mg/kg) could significantly enhance the level of white blood cells which should be reduced by cyclophosphamide in mice. Strengthening body resistance test suggested that Kang'aiping granule could improve the immune function of mice. Kang'aiping granule could significantly inhibit the viability of BGC-823 cell in vitro in a dose-dependent manner. Conclusion Kang'aiping granule has definite anticancer effects in vivo and in vitro on mice and its mechanism may be correlated with inhibiting tumor cell growth and improving immune function of mice.关键词
抗肿瘤剂(中药)/药理学/环磷酰胺Key words
antineoplastic agents (TCD)/pharmacology/ cyclophosphamide分类
医药卫生引用本文复制引用
胡宗涛,魏倩,董六一..抗癌平颗粒剂的体内外抗肿瘤作用[J].安徽医科大学学报,2011,46(3):245-248,4.
