安徽医科大学学报2011，Vol.46Issue(3)：223-227,5.
子宫内膜样腺癌中MDM2、Livin和Caspase-3蛋白及mRNA的表达
Expressions of MDM2, Livin and Caspase-3 protein and mRNA in endometrial adenocarcinomas
摘要
Abstract
Objective To investigate the relationship of the expression of MDM2,Livin and Caspase-3 protein and mRNA in the development of endometrioid adenocarcinoma (EA). Methods The expression levels of MDM2, Livin and Caspase-3 proteins and mRNA in EA tissues (n = 72), endometrial hyperplasia tissues (n = 60) and normal tissues ( n = 30) were examined by tissue microarray technique, immunohistochemistry( SP method) and in situ hybridization method. Results The positive expression rates of MDM2, Livin and Caspase-3 protein and mRNA in EA were respectively 80. 6％ ( 58/72 ), 80. 6％ ( 58/72 ), 33.3％ ( 24/72 ) and 73.6％ ( 53/72 ), 75.0％ ( 54/72 ),27.8％ (20/72). The positive rates of both MDM2 and Livin protein and mRNA in EA were higher than that in normal endometrium and endometrial hyperplasia( P ＜ 0. 01 ). However, the positive rate of Caspase-3 in EA was lower than that in normal endometrium and endometrial hyperplasia( P ＜ 0. 01 ). The positive expressions of MDM2 protein and mRNA were not related to the histological grade, FIGO stage, depth of invasion and lymph node metastasis. The positive expressions of Livin and Caspase-3 protein and mRNA were related to histological grade (P ＜ 0. 01 ,P ＜0.05 ), but they were not related to FIGO stage, depth of invasion and the lymph node metastasis. The expressions of MDM2, Livin and Caspase-3 protein were positively correlated with their mRNA. The expression of Livin was negatively correlated Caspase-3. Conclusion The expressions of MDM2, Livin and Caspase-3 protein and mRNA correlate with the dedvelopment and progression of EA, which may be valuable biomarkers to detect the early carcinogenesis and prognosis of EA.关键词
子宫内膜肿瘤/半胱氨酸天冬氨酸蛋白酶3Key words
endometrial neoplasms /Caspase-3分类
医药卫生引用本文复制引用
郭真理,陈柯,王晓秋,胡闻..子宫内膜样腺癌中MDM2、Livin和Caspase-3蛋白及mRNA的表达[J].安徽医科大学学报,2011,46(3):223-227,5.基金项目
安徽省卫生厅医学科研项目(编号:2010B010) （编号:2010B010）
